Guest post from Tom Branson

Inside Back Cover: Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor (Angew. Chem. Int. Ed. 38/2014)
Angewandte Chemie International Edition
Volume 53, Issue 38, pages 10251-10251, 22 JUL 2014
DOI: 10.1002/anie.201406845
http://onlinelibrary.wiley.com/doi/10.1002/anie.201406845/full#car1

Science fiction often predicts future advances and has even prompted the development of some technologies. So should we be taking advantage of this association? Can we use a science fiction setting to showcase science fact? That idea is exactly what the latest cover of Angewandte Chemie has attempted to do. (more…)

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Guest post by Jen Dougan

Of all the components of a cooked breakfast, a perfectly fried egg is arguably the most important. It’s for that reason, despite the myriad of other factors to consider – size/weight/colour/celebrity chef endorsement – that a frying pan’s non-stick credentials are key.

Polytetrafluoroethylene (PTFE), the ‘big daddy’ of non-stick, was discovered by accident in 1938. While attempting to make a new CFC refrigerant, American industrial research chemist Roy J. Plunkett noticed that a cylinder of tetrafluoroethylene had stopped flowing but its weight suggested something still inside. In his own words, ‘more out of curiosity… than anything else,’ Plunkett and his assistant cut open the cylinder to discover it was packed at the bottom and sides with a white, waxy solid. Analysis showed that the material was chemically inert, thermally and electrically resistant, and had very low surface friction. (more…)

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My name is Jen Dougan and I am a Field Applications Scientist with an SME, developing diagnostic tools for clinical analysis. My job involves working with our R&D teams and customers in the field to drive and support product and applications development.

I recently moved into this position after a PhD and two post-docs (and a brief stint in science policy) in bio-nano-analytical chemistry. What I’ve loved about the transition into this role is the chance to ask questions and provide answers in a fast-paced, rigorous environment. It’s been fantastic to see some of the techniques used through my PhD and post-docs in action in a clinical setting.

Real world applications of chemical research are a central theme of this blog. I’ll be contributing regular posts here, to explore the chemistry in our every day lives. From the clothes we wear to the goods we use, it really is a chemical world.

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Guest post by JessTheChemist

Scientists have a responsibility, or at least I feel I have a responsibility, to ensure that what I do is for the benefit of the human race’ – Harry Kroto

Thank you for your nominations for this month’s blog post. It was great to see so many of you getting involved in this series, highlighting interesting Nobel laureates for me to cover. However, I could only pick one winner, so I decided to write about Harry Kroto, inspired by this tweet from Bolton School:

Harry Kroto has a formidable CV. Not only is he a highly distinguished and talented chemist, but he does a great deal to improve the teaching of chemistry to future generations. This has included setting up the not-for-profit Vega Science Trust, which helps scientists communicate with the public at large, and even returning to his childhood school to build Buckyballs with students. (more…)

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‘As for monkshood and wolfsbane, they are the same plant, which also goes by the name of aconite.’ – Severus Snape, Harry Potter and the Philosophers Stone by J. K. Rowling

In Harry Potter’s very first potions lesson he learnt about the magical properties of aconite. Muggle chemists, it seems, are only one step behind the magical world.

©istock

Aconitine – spelt slightly differently by scientists – has a highly complex structure that has never before been synthesised in the lab. But now, Duncan Gill from the University of Huddersfield, UK, has been awarded a £133,481 grant to develop a synthetic route to obtain this illusive molecule.

Attempts to make aconitine began after Czech chemist Karel Wiesner revealed its chemical structure in 1959. Weisner went on to publish several papers on the synthesis of alkaloids and terpenoids, an important initial step towards making the molecule. However, it wasn’t until last year that a major milestone was reached, when a team of researchers from the Memorial Sloan Kettering Cancer Institute, New York, announced the total synthesis of the related compound, neofinaconitine. Building on the work of his predecessors, Gill will have to develop new chemical methods to reach his target molecule.

If successful, Gill, who has previously worked as a process chemist at AstraZeneca, will need to be particularly careful when handling this compound. Aconitine is a potent neurotoxin and has been dubbed the ‘Queen of poisons’. One of the most notable references to aconitine comes from William Shakespeare’s Romeo and Juliet: it is the main ingredient in the toxic potion drunk by Romeo with fatal consequences.

The grant has been provided by the Leverhulme Trust and will be enough to employ a full-time post-doctoral advisor. Only time will tell if they can bring this fictional favourite to life in a laboratory setting.

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Guest post by Heather Cassell

©Shutterstock

Sometimes it happens when I’m reading a research paper, sometimes when I’m doing an experiment, analysing data or learning a new technique; or more often when I’m reading Twitter. It’s that moment when you discover something new and interesting, or re-discover a fact that you used to know, and it makes you pause and think ‘ooh, that’s interesting’. For me the discovery usually leads to a massive detour into reading things other than those I was meant to be reading or working on, but I always learn something from it and sometimes it’s actually relevant to my work. Whether it directly affects research or not, the ‘ooh, that’s interesting’ moment is at the heart of scientific investigation. (more…)

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Guest post by Rowena Fletcher-Wood

Scurvy plagued early sailors, and although many treatments were tried and promoted, a simple cure was masked for centuries behind a series of mistakes and misunderstandings.

This story begins at sea, long into a voyage after the fresh food stock had long run out and the sailors were left with only grains, hardtack and cured meats to eat. The sailors would become desperate as scurvy began to set in. Sailors were lost to scurvy in vast numbers, with estimates as high as two million lives lost between 1500–1800 AD.

©Shutterstock

(more…)

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Guest post from Tom Branson

A bright new reaction scheme has found its way to the cover of Inorganic Chemistry. Not content with old standard representations, this journal has been given the professional touch.

Framing metal complexes

The image puts a well needed shine on the conventional reaction scheme and perhaps suggests that we should now be teaching undergrads to paint as well as honing their ChemDraw skills. Two states of a porphyrin derivative complexed with zinc are shown here framed in audacious, golden swirls. And why not? If you’re proud of your work then go ahead and put a huge golden frame around it. (more…)

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Guest post by JessTheChemist

‘The noblest exercise of the mind within doors, and most befitting a person of quality, is study’ – Ramsay

A few years ago I had the pleasure of meeting Jack Dunitz at the Swiss Federal Institute of Technology (ETH) in Zurich. Little did I know that he was the academic great-great-grandson of the UK’s first chemistry Nobel Laureate, Sir William Ramsay. After discovering this connection, I decided to delve deeper to see which other chemistry legends Ramsay is connected to.

Ramsay began his career as an organic chemist, but his prominent discoveries were in the field of inorganic chemistry. At the meeting of the British Association in August 1894, Ramsay and Lord Rayleigh both announced the discovery of argon, after independent research. Ramsay then discovered helium in 1895 and systematically researched the missing links in this new group of elements to find neon, krypton, and xenon1. These findings led to Ramsay winning his Nobel prize in 1904 in ‘recognition of his services in the discovery of the inert gaseous elements in air, and his determination of their place in the periodic system’. (more…)

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I am a postdoctoral fellow at the Institute of Process Research and Development (iPRD) at the University of Leeds. My research is on the synthesis of chiral amines relevant to the pharmaceutical industry but I have a general interest in organic chemistry, catalysis and sustainable methodologies. When I am not in the lab, I blog at The Organic Solution on a range of topics including chemical research, postdoc life and outreach experiences. Recently, I have become interested in the connection between chemists across the globe which has led me to create an academic twitter tree.

To continue this academic tree theme, this blog will explore certain strands of the chemistry Nobel Laureate family tree using the Royal Society of Chemistry’s Chemical Connections. The blog will delve into the life and heritage of different chemistry Nobel Laureates and, amongst other things, we shall find out if having a Nobel winner in your lineage could have an effect on your career, for example, does having a Nobel winner in your ancestry mean you are more likely to achieve academic greatness? If there is a Nobel winner that you would like to see featured, please get in touch.

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